Tennessee football vs. East Tennessee State final odds and a prediction

The Vols should cruise to a Week 2 win.
2025 Aflac Kickoff Game - Syracuse v Tennessee
2025 Aflac Kickoff Game - Syracuse v Tennessee | Kevin C. Cox/GettyImages

Who's ready for the home-opener to get here? On Saturday, Knoxville is going to be packed for the first game at Neyland Stadium of the new campaign. Fans are ready to remind everyone why games at Tennessee football showcase the best environment in the country.

As for the action on the field, Tennessee's confidence is riding high after taking care of business against Syracuse in Week 1. What will the Vols be able to get done for an encore against East Tennessee State? Well, the oddsmakers think they're going to cruise to a win and barely break a sweat in doing so.

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Tennessee football is favored by 42.5 points against East Tennessee State

That's right, with the Week 2 tilt right around the corner, Tennessee is favored by 42.5 points. With the greatest of respect for East Tennessee State, that line seems pretty fair, with both -110 odds for both the over and under.

This is going to be a chance for quarterback Joey Aguilar and his pass-catchers to keep building a ton of chemistry with one another. That was on full display against Syracuse, with Aguilar throwing for 247 yards and his three touchdowns.

On the ground, it was a day to remember for Duke transfer Star Thomas, DeSean Bishop and Peyton Lewis. In total, Tennessee rushed for 248 yards, which was much more than anyone anticipated would be on the way. The offense was clicking in every way possible.

Defensively, There were some struggles showcased that DC Tim Banks is going to want to clean up as soon as possible, especially with Georgia on the schedule next for Sept. 13. Luckily for Tennessee, Banks and Josh Heupel, East Tennessee State is not expected to give the Vols too many problems at Neyland.

Barring a catastrophic letdown, the Vols should improve to 2-0 and be a Top 15-20 team leading up to the highly-anticipated meeting against Kirby Smart and Co. Look for Tennessee to post a dominant win - we're picking the Vols to come out on top 48-7.